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CS-W001157 4
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2-Iodo-5-methylpyrazine

  • CAS No. 914452-70-3

  • Cat. No. CS-0059962
  • Purity≥96%
  • MDL No.MFCD08705755

*For research and further manufacturing use only, not for direct human use.

2-Iodo-5-methylpyrazine|CS-0059962

Structure of 914452-70-3

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General Information

  • CAS No. 914452-70-3
  • Cat. No. CS-0059962
  • Purity ≥96%
  • MDL No. MFCD08705755
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅IN₂
  • Molecular Weight 220.01
  • Synonym(s) None
  • SMILES C=1(N=CC(I)=NC1)C

Description

2-Iodo-5-methylpyrazine is a bench-stable, moisture-tolerant heterocyclic iodide featuring a methyl group at the 5-position and an iodine atom at the 2-position. This configuration enables direct coupling in cross-coupling reactions, facilitating efficient access to functionalized pyrazine scaffolds. The electron-deficient core supports palladium-catalyzed transformations with high regioselectivity.

Application

2-Iodo-5-methylpyrazine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions with broad functional group tolerance. Its iodine moiety facilitates efficient C–C and C–heteroatom bond formation, while the methyl group enhances solubility and stability. This compound functions reliably in standard coupling protocols, offering predictable reactivity for constructing complex pyrazine-based scaffolds in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.38962
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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