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CS-W001157 4
Total: USD 88.00

2,3-Difluoro-6-nitrotoluene

  • CAS No. 914348-35-9

  • Cat. No. CS-W023220
  • Purity≥97%
  • MDL No.MFCD08706407

*For research and further manufacturing use only, not for direct human use.

2,3-Difluoro-6-nitrotoluene|CS-W023220

Structure of 914348-35-9

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General Information

  • CAS No. 914348-35-9
  • Cat. No. CS-W023220
  • Purity ≥97%
  • MDL No. MFCD08706407
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO₂
  • Molecular Weight 173.12
  • Synonym(s) 1,2-Difluoro-3-methyl-4-nitrobenzene
  • SMILES CC1=C([N+]([O-])=O)C=CC(F)=C1F

Description

2,3-Difluoro-6-nitrotoluene features a trifunctional aromatic core with electron-withdrawing nitro and fluorine substituents positioned for orthogonal reactivity. This bench-stable compound integrates readily into C–H functionalization cascades and serves as a key intermediate in the synthesis of fluorinated heterocycles and bioactive pharmaceuticals.

Application

2,3-Difluoro-6-nitrotoluene serves as a valuable building block for fluorinated aromatic systems, enabling efficient access to substituted heterocycles and pharmaceutical intermediates. Its ortho-difluoro substitution pattern facilitates directed metallation and subsequent functionalization, while the nitro group provides a robust handle for reduction and coupling reactions. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, simplifying purification and integration into multi-step sequences.

Synthesis

  • Route1

    References

    • WO2007/36715 A2, ; Page/Page column 48-49 ; WO 2007/036715 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.14
  • LogP   2.18142
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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