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CS-W001157 4
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(S)-3-Phenylmorpholine

  • CAS No. 914299-79-9

  • Cat. No. CS-0038114
  • Purity≥96%
  • MDL No.MFCD11016232

*For research and further manufacturing use only, not for direct human use.

(S)-3-Phenylmorpholine|CS-0038114

Structure of 914299-79-9

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General Information

  • CAS No. 914299-79-9
  • Cat. No. CS-0038114
  • Purity ≥96%
  • MDL No. MFCD11016232
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃NO
  • Molecular Weight 163.22
  • Synonym(s) T6N DOTJ CR &&S Form
  • SMILES C1=CC=C(C=C1)[C@H]2COCCN2

Description

(S)-3-Phenylmorpholine is a chiral morpholine derivative featuring a phenyl group at the 3-position, offering enhanced stereochemical control in asymmetric synthesis. This bench-stable compound integrates readily into medicinal chemistry campaigns, providing a rigid, electron-rich scaffold for ligand development and bioactive molecule design.

Application

(S)-3-Phenylmorpholine serves as a versatile chiral building block in medicinal chemistry, enabling the construction of bioactive heterocycles through established coupling and functionalization protocols. Its phenyl-substituted morpholine core exhibits favorable bench stability and compatibility with standard synthetic workflows, facilitating efficient access to pharmaceutically relevant scaffolds.

Synthesis

  • Route1

    References

    • Alexander, Rikki; Balasundaram, Ahrani; Batchelor, Mark; Brookings, Daniel; Crepy, Karen; Crabbe, Tom; Deltent, Marie-France; Driessens, Frank; Gill, Andrew; Harris, Sue; Hutchinson, Gillian; Kulisa, Claire; Merriman, Mark; Mistry, Prakash; Parton, Ted; Turner, James; Whitcombe, Ian; Wright, Sara Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 15 p. 4316 - 4320
  • Route2

    References

    • Angewandte Chemie - International Edition, , vol. 52, # 20 p. 5319 - 5322 Angew. Chem., , vol. 125, # 20 p. 5427 - 5430,4
  • Route3
    • (S)-2-chloro-N-(2-hydroxy-1-phenylethyl)acetamide|CS-0571507
      291545-74-9
    • ~%
    • In-stock
      (S)-3-Phenylmorpholine|CS-0038114
      914299-79-9

    References

    • Angewandte Chemie - International Edition, , vol. 52, # 20 p. 5319 - 5322 Angew. Chem., , vol. 125, # 20 p. 5427 - 5430,4

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   1.3475
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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