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CS-W001157 4
Total: USD 88.00

3-Amino-2-fluorobenzoic acid

  • CAS No. 914223-43-1

  • Cat. No. CS-W019562
  • Purity≥98%
  • MDL No.MFCD06797827

*For research and further manufacturing use only, not for direct human use.

3-Amino-2-fluorobenzoic acid|CS-W019562

Structure of 914223-43-1

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General Information

  • CAS No. 914223-43-1
  • Cat. No. CS-W019562
  • Purity ≥98%
  • MDL No. MFCD06797827
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES O=C(O)C1=CC=CC(N)=C1F

Description

3-Amino-2-fluorobenzoic acid features a strategically positioned amino group adjacent to a fluorine atom on the aromatic ring, enabling unique electronic and steric tuning. This combination enhances its utility in medicinal chemistry scaffolds and as a building block for bioactive compounds. The carboxylic acid moiety offers ready derivatization potential under standard coupling conditions.

Application

3-Amino-2-fluorobenzoic acid serves as a versatile building block for medicinal chemistry and agrochemical synthesis, enabling direct access to fluorinated aromatic scaffolds. Its ortho-fluoro and amino groups facilitate selective functionalization and coupling reactions, while the carboxylic acid group supports amide formation and derivatization. The compound exhibits good bench stability and is compatible with standard purification methods, making it a practical choice for iterative synthetic campaigns in API development.

Synthesis

  • Route1

    References

    • US2009/286783 A1, ; Page/Page column 57-58 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   1.1061
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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