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Structure of 914208-15-4
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8-Bromoquinoline-2-carboxylic acid features a bromine substituent at the 8-position and a carboxylic acid group at the 2-position of the quinoline core, enabling direct functionalization in transition-metal-catalyzed coupling reactions. The electron-deficient heterocycle enhances reactivity in cross-coupling protocols, while the carboxylic acid facilitates derivatization via amide or ester formation. This scaffold delivers structural rigidity and improved solubility in polar solvents for medicinal chemistry applications.
8-Bromoquinoline-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into quinoline-based scaffolds via standard coupling reactions. Its bromine and carboxylic acid functionalities provide orthogonal handles for Pd-catalyzed cross-couplings and amide formation, offering robust access to diverse heterocyclic architectures. The compound exhibits excellent bench stability and facilitates straightforward purification, supporting scalable synthesis and integration into complex molecular frameworks.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: