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CS-W001157 4
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5-Bromo-2-methylpyridin-3-ol

  • CAS No. 91420-25-6

  • Cat. No. CS-W022314
  • Purity≥97%
  • MDL No.MFCD12024425

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-methylpyridin-3-ol|CS-W022314

Structure of 91420-25-6

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General Information

  • CAS No. 91420-25-6
  • Cat. No. CS-W022314
  • Purity ≥97%
  • MDL No. MFCD12024425
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrNO
  • Molecular Weight 188.02
  • Synonym(s) 5-Bromo-3-hydroxy-2-methylpyridine
  • SMILES BrC1=CN=C(C(=C1)O)C

Description

5-Bromo-2-methylpyridin-3-ol features a bromine substituent at the 5-position and a methyl group at the 2-position, flanking a phenolic hydroxyl on a pyridine core. This electron-deficient heterocycle integrates readily into cross-coupling reactions, offering enhanced stability under standard conditions. The hydroxyl group enables direct functionalization or metal coordination, streamlining access to complex scaffolds in medicinal chemistry and materials science.

Application

5-Bromo-2-methylpyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its bromine substituent. The phenolic hydroxyl group offers orthogonal reactivity for derivatization, while the methyl and pyridine functionalities provide stability and compatibility with standard synthetic workflows. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for iterative synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.85812
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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