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CS-W001157 4
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2-Fluorophenethyl bromide

  • CAS No. 91319-54-9

  • Cat. No. CS-0139578
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Fluorophenethyl bromide|CS-0139578

Structure of 91319-54-9

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General Information

  • CAS No. 91319-54-9
  • Cat. No. CS-0139578
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrF
  • Molecular Weight 203.05
  • Synonym(s) 2-Fluorophenethylebromide
  • SMILES FC1=CC=CC=C1CCBr

Description

2-Fluorophenethyl bromide features a fluorinated phenethyl scaffold with high reactivity at the benzylic position. This bench-stable halide integrates readily into nucleophilic substitution reactions, enabling efficient construction of fluorinated aromatic building blocks for pharmaceutical and agrochemical synthesis.

Application

2-Fluorophenethyl bromide serves as a versatile building block in medicinal chemistry, enabling efficient C–C bond formation via palladium-catalyzed cross-coupling reactions. Its benzylic bromide functionality exhibits high reactivity with nucleophiles and transition metal catalysts, while the ortho-fluoro substituent provides metabolic stability and modulates electronic properties. The compound demonstrates excellent bench stability and compatibility with diverse functional groups, facilitating straightforward purification and integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • Houghton, Roy P.; Voyle, Martyn; Price, Raymond Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 5 p. 925 - 931
  • Route2

    References

    • Tetrahedron Asymmetry, , vol. 12, # 4 p. 585 - 596
  • Route3

    References

    • Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 5 p. 925 - 931

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H302-H401-H411
Precautionary Statements : P210-P264-P270-P273-P280-P370+P378-P391-P403+P235-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.7631
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   2

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