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CS-W001157 4
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2-Methyl-2,7-diazaspiro[4.4]nonane dihydrochloride

  • CAS No. 91188-26-0

  • Cat. No. CS-0000848
  • Purity≥97%
  • MDL No.MFCD13185105

*For research and further manufacturing use only, not for direct human use.

2-Methyl-2,7-diazaspiro[4.4]nonane dihydrochloride|CS-0000848

Structure of 91188-26-0

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General Information

  • CAS No. 91188-26-0
  • Cat. No. CS-0000848
  • Purity ≥97%
  • MDL No. MFCD13185105
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈Cl₂N₂
  • Molecular Weight 213.15
  • Synonym(s) 2-METHYL-2,7-DIAZASPIRO[4.4]NONANE 2HCL
  • SMILES CN(CC1)CC21CNCC2.Cl.Cl

Description

2-Methyl-2,7-diazaspiro[4.4]nonane dihydrochloride features a rigid spirocyclic scaffold with two nitrogen atoms at strategic positions, delivering enhanced basicity and structural stability. The protonated form ensures high solubility in aqueous media, enabling efficient use in medicinal chemistry applications. This bench-stable salt serves as a key building block for constrained heterocyclic systems in drug discovery pipelines.

Application

2-Methyl-2,7-diazaspiro[4.4]nonane dihydrochloride serves as a rigid, bicyclic amine scaffold enabling precise spatial positioning of functional groups in medicinal chemistry. Its protonated form enhances solubility and stability in aqueous media, facilitating downstream conjugation and salt formation. The molecule exhibits excellent functional group tolerance and serves as a key building block for spirocyclic heterocycles, particularly in the synthesis of kinase inhibitors and CNS-targeted compounds.

Synthesis

  • Route1
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      91189-26-3
    • ~%
    • In-stock
      2-Methyl-2,7-diazaspiro[4.4]nonane dihydrochloride|CS-0000848
      91188-26-0

    References

    • Warner-Lambert Company Patent: US4604401 A1, 1986 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   1.1452
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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