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CS-W001157 4
Total: USD 88.00

5-(Benzyloxy)-2,4-dichloropyrimidine

  • CAS No. 91183-17-4

  • Cat. No. CS-W022251
  • Purity≥97%
  • MDL No.MFCD16658924

*For research and further manufacturing use only, not for direct human use.

5-(Benzyloxy)-2,4-dichloropyrimidine|CS-W022251

Structure of 91183-17-4

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General Information

  • CAS No. 91183-17-4
  • Cat. No. CS-W022251
  • Purity ≥97%
  • MDL No. MFCD16658924
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₈Cl₂N₂O
  • Molecular Weight 255.10
  • Synonym(s) 2,4-Dichloro-5-(phenylmethoxy)pyrimidine
  • SMILES ClC1=NC(Cl)=NC=C1OCC2=CC=CC=C2

Description

5-(Benzyloxy)-2,4-dichloropyrimidine features a benzyloxy substituent at the 5-position, enhancing solubility and stability in organic synthesis. The electron-deficient pyrimidine core facilitates nucleophilic substitution reactions. This compound serves as a key intermediate in the construction of bioactive heterocycles and kinase inhibitors under standard conditions.

Application

5-(Benzyloxy)-2,4-dichloropyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The benzyloxy group offers orthogonal stability under standard reaction conditions while allowing selective deprotection when required. Its dichloropyrimidine core facilitates nucleophilic substitution at C5, supporting the construction of diverse heterocyclic scaffolds relevant to kinase inhibitors and antiviral agents. The compound exhibits excellent bench stability and compatibility with common purification methods.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.01
  • LogP   3.3624
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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