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CS-W001157 4
Total: USD 88.00

(2-Fluoro-6-iodophenyl)methanol

  • CAS No. 911825-94-0

  • Cat. No. CS-0036123
  • Purity≥98%
  • MDL No.MFCD09910144

*For research and further manufacturing use only, not for direct human use.

(2-Fluoro-6-iodophenyl)methanol|CS-0036123

Structure of 911825-94-0

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General Information

  • CAS No. 911825-94-0
  • Cat. No. CS-0036123
  • Purity ≥98%
  • MDL No. MFCD09910144
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FIO
  • Molecular Weight 252.02
  • Synonym(s) 2-Fluoro-6-iodobenzyl alcohol
  • SMILES OCC1=C(I)C=CC=C1F

Description

This fluorinated arylmethanol features a strategically positioned iodine atom enabling direct functionalization in cross-coupling reactions. The electron-withdrawing fluorine enhances reactivity while maintaining stability under standard conditions, making it ideal for constructing complex biaryl architectures in medicinal chemistry and materials science applications.

Application

(2-Fluoro-6-iodophenyl)methanol serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The ortho-fluoro substituent enhances reactivity in Suzuki-Miyaura and Buchwald-Hartwig couplings, while the benzylic alcohol functionality offers straightforward derivatization via oxidation or protection. Its bench-stable nature and compatibility with diverse reaction conditions make it a practical choice for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Fan, Yi Chiao; Kwon, Ohyun Organic Letters, 2012 , vol. 14, # 13 p. 3264 - 3267

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P264-P270-P330

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.9226
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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