8-Chloro-2-methyl-1,5-naphthyridine

Name: 8-Chloro-2-methyl-1,5-naphthyridine
Brand: ChemScene
Availability: InStock
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CAS No. 911389-21-4
Cat. No. CS-0179427
Purity≥97%
MDL No.MFCD19690237

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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8-Chloro-2-methyl-1,5-naphthyridine|CS-0179427

Structure of 911389-21-4

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Description

8-Chloro-2-methyl-1,5-naphthyridine is a bench-stable heterocyclic building block featuring a chlorinated naphthyridine core with a methyl substituent at the 2-position. This electron-deficient scaffold integrates readily into pharmaceutical and agrochemical synthesis, offering enhanced reactivity in cross-coupling and nucleophilic substitution processes.

Application

8-Chloro-2-methyl-1,5-naphthyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C-8 position via palladium-catalyzed cross-coupling. Its methyl group enhances metabolic stability and provides a handle for further derivatization. The molecule exhibits excellent bench stability and facilitates efficient synthesis of kinase inhibitors and other bioactive heterocycles through orthogonal reactivity with nucleophiles and transition metal catalysts.

General Information

CAS No. 911389-21-4
Cat. No. CS-0179427
Purity ≥97%
MDL No. MFCD19690237
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₇ClN₂
Molecular Weight 178.62
Synonym(s) 8-Chloro-2-methyl-1,5phthyridine
SMILES CC1=NC2=C(Cl)C=CN=C2C=C1

Computational Chemistry Data

TPSA 25.78
LogP 2.59162
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Naphthyridine compounds

Key Words

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8-Chloro-2-methyl-1,5-naphthyridine

CAS No. 911389-21-4

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