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CS-W001157 4
Total: USD 88.00

3-(Benzyloxy)-6-chloropyridazine

  • CAS No. 91063-19-3

  • Cat. No. CS-0019360
  • Molecule weight220.66
  • Purity≥98%
  • MDL No.MFCD00270292

*For research and further manufacturing use only, not for direct human use.

3-(Benzyloxy)-6-chloropyridazine|CS-0019360

Structure of 91063-19-3

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General Information

  • CAS No. 91063-19-3
  • Cat. No. CS-0019360
  • Purity ≥98%
  • MDL No. MFCD00270292
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₉ClN₂O
  • Molecular Weight 220.66
  • Synonym(s) 3-CHLORO-6-BENZYLOXYPYRIDAZINE
  • SMILES ClC1=NN=C(OCC2=CC=CC=C2)C=C1

Description

3-(Benzyloxy)-6-chloropyridazine features a benzyl ether substituent at the 3-position and a chlorine atom at the 6-position of the pyridazine core. This combination imparts enhanced stability and tailored electronic properties, enabling direct incorporation into synthetic routes for pharmaceutical intermediates and functional materials.

Application

3-(Benzyloxy)-6-chloropyridazine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridazine scaffolds. The benzyloxy group provides orthogonal protection for phenolic functionalities, while the 6-chloro handle facilitates palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with standard synthetic workflows make it well-suited for iterative library synthesis and API intermediate development.

Synthesis

  • Route1
    • In-stock
      3,6-Dichloropyridazin|CS-0015357
      141-30-0
    • Sodium benzyloxide|CS-0636172
      20194-18-7
    • ~79%
    • In-stock
      3-(Benzyloxy)-6-chloropyridazine|CS-0019360
      91063-19-3

    References

    • BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG Patent: WO2007/48802 A1, 2007 ; Location in patent: Page/Page column 79 ;
  • Route2

    References

    • Pfizer Products Inc. Patent: EP1236720 A1, 2002 ; Location in patent: Page 28 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.01
  • LogP   2.709
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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