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CS-W001157 4
Total: USD 88.00

2,5-Dimethylindoline

  • CAS No. 90874-56-9

  • Cat. No. CS-0152911
  • Purity≥96%
  • MDL No.MFCD16300825

*For research and further manufacturing use only, not for direct human use.

2,5-Dimethylindoline|CS-0152911

Structure of 90874-56-9

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General Information

  • CAS No. 90874-56-9
  • Cat. No. CS-0152911
  • Purity ≥96%
  • MDL No. MFCD16300825
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃N
  • Molecular Weight 147.22
  • Synonym(s) 2,3-dihydro-2,5-diMethyl-1H-Indole
  • SMILES CC1=CC2=C(C=C1)NC(C)C2

Description

2,5-Dimethylindoline is a bench-stable, electron-rich heterocycle featuring a substituted indoline core. The methyl groups at the 2- and 5-positions enhance steric protection and stability while preserving reactivity in transition metal-catalyzed couplings. This scaffold integrates readily into complex molecular architectures, particularly in medicinal chemistry and materials science applications.

Application

2,5-Dimethylindoline serves as a versatile heterocyclic building block in medicinal chemistry and synthetic organic research. Its electron-rich aromatic core facilitates palladium-catalyzed cross-coupling reactions, while the methyl substituents enhance metabolic stability and modulate lipophilicity. The compound exhibits excellent bench stability, ease of purification, and compatibility with common functional groups, enabling efficient incorporation into diverse molecular scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.35152
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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