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CS-W001157 4
Total: USD 88.00

5-Fluoro-1H-indole-4-carboxylic acid

  • CAS No. 908600-70-4

  • Cat. No. CS-0141828
  • Purity≥97%
  • MDL No.MFCD16037409

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-1H-indole-4-carboxylic acid|CS-0141828

Structure of 908600-70-4

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General Information

  • CAS No. 908600-70-4
  • Cat. No. CS-0141828
  • Purity ≥97%
  • MDL No. MFCD16037409
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆FNO₂
  • Molecular Weight 179.15
  • Synonym(s) 1H-Indole-4-carboxylic acid, 5-fluoro-
  • SMILES O=C(C1=C(F)C=CC2=C1C=CN2)O

Description

5-Fluoro-1H-indole-4-carboxylic acid features a fluorinated indole core with a carboxylic acid group at the 4-position, offering enhanced electron-withdrawing character and improved metabolic stability. This scaffold integrates readily into bioactive molecules for medicinal chemistry campaigns targeting CNS agents and kinase inhibitors.

Application

5-Fluoro-1H-indole-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of indole-based scaffolds with enhanced metabolic stability. Its carboxylic acid functionality facilitates direct amidation, esterification, and coupling reactions, while the fluorinated position offers favorable electronic effects for target engagement. The compound exhibits good bench stability and is compatible with standard peptide coupling protocols, making it suitable for high-throughput library generation and API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   2.0052
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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