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CS-W001157 4
Total: USD 88.00

1-(2,3-Dihydrobenzofuran-5-yl)ethanone

  • CAS No. 90843-31-5

  • Cat. No. CS-M0161
  • Purity≥97%
  • MDL No.MFCD00068033

*For research and further manufacturing use only, not for direct human use.

1-(2,3-Dihydrobenzofuran-5-yl)ethanone|CS-M0161

Structure of 90843-31-5

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General Information

  • CAS No. 90843-31-5
  • Cat. No. CS-M0161
  • Purity ≥97%
  • MDL No. MFCD00068033
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O₂
  • Molecular Weight 162.19
  • Synonym(s) Ethanone, 1-(2,3-dihydro-5-benzofuranyl)-
  • SMILES O=C(C)C1=CC=C(OCC2)C2=C1

Description

1-(2,3-Dihydrobenzofuran-5-yl)ethanone features a fused heterocyclic core with a ketone-bearing side chain, offering enhanced solubility and stability in polar solvents. This scaffold integrates readily into bioactive molecule design, particularly for CNS-targeted compounds and synthetic intermediates requiring metabolic resistance.

Application

1-(2,3-Dihydrobenzofuran-5-yl)ethanone serves as a versatile building block in medicinal chemistry, enabling the efficient construction of bioactive heterocycles. Its benzofuran scaffold offers enhanced metabolic stability and favorable pharmacokinetic properties, while the acetyl group facilitates downstream functionalization via nucleophilic substitution or reduction. The compound exhibits excellent bench stability and is compatible with standard synthetic protocols, simplifying purification and integration into multi-step syntheses.

Synthesis

  • Route1
    • In-stock
      Coumaran|CS-M0160
      496-16-2
    • null|null
      75-36-5
    • ~99%
    • In-stock
      1-(2,3-Dihydrobenzofuran-5-yl)ethanone|CS-M0161
      90843-31-5

    References

    • KOWA COMPANY, LTD. Patent: US2010/280013 A1, 2010 ; Location in patent: Page/Page column 16 ;
  • Route2

    References

    • AUCKLAND UNISERVICES LIMITED Patent: WO2006/104406 A1, 2006 ; Location in patent: Page/Page column 135 ;
  • Route3
    • null|null
      1191-99-7
    • null|null
      75-36-5
    • ~94%
    • In-stock
      1-(2,3-Dihydrobenzofuran-5-yl)ethanone|CS-M0161
      90843-31-5

    References

    • Abbott Laboratories Patent: US5767144 A1, 1998 ; US 5767144 A

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.8241
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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