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CS-W001157 4
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N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine

  • CAS No. 90390-11-7

  • Cat. No. CS-0077585
  • Purity≥98%
  • MDL No.MFCD04115411

*For research and further manufacturing use only, not for direct human use.

N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine|CS-0077585

Structure of 90390-11-7

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General Information

  • CAS No. 90390-11-7
  • Cat. No. CS-0077585
  • Purity ≥98%
  • MDL No. MFCD04115411
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀F₃N
  • Molecular Weight 189.18
  • Synonym(s) N-methyl-1-[4-(trifluoromethyl)phenyl]methanamine
  • SMILES CNCC1=CC=C(C(F)(F)F)C=C1

Description

N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine is a bench-stable, moisture-tolerant amine featuring a para-trifluoromethyl aryl group that imparts strong electron-withdrawing character. This structure enables efficient coupling in C–N bond formation and serves as a key building block for bioactive molecules in medicinal chemistry.

Application

N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard amine functionalization. Its trifluoromethylated aryl group enhances metabolic stability and lipophilicity, while the N-methylated primary amine facilitates downstream derivatization via alkylation, acylation, or reductive amination. The compound exhibits good bench stability and is compatible with common purification methods, making it suitable for scalable synthesis workflows.

Synthesis

  • Route1
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      911101-44-5
    • ~%
    • In-stock
      N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine|CS-0077585
      90390-11-7

    References

    • Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1111 - 1118
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 27, # 9 p. 1111 - 1118
  • Route3
    • In-stock
      1-(Bromomethyl)-4-(trifluoromethyl)benzene|CS-W018337
      402-49-3
    • null|null
      74-89-5
    • ~%
    • In-stock
      N-Methyl-1-(4-(trifluoromethyl)phenyl)methanamine|CS-0077585
      90390-11-7

    References

    • Journal of Medicinal Chemistry, , vol. 41, # 15 p. 2882 - 2891

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P264-P271-P280-P301+P330+P331-P304+P340-P363-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.4248
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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