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Structure of 902743-27-5
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8-Bromo-2-chloroquinoline-4-carboxylic acid features a sterically hindered quinoline core with strategically positioned halogen substituents, enabling direct functionalization in cross-coupling and bioconjugation workflows. The carboxylic acid group provides a robust anchor for amide bond formation, while the electron-deficient aromatic system enhances reactivity in transition metal-catalyzed transformations. This compound serves as a modular scaffold for medicinal chemistry and materials synthesis under standard conditions.
8-Bromo-2-chloroquinoline-4-carboxylic acid serves as a versatile building block for the synthesis of quinoline-based scaffolds in medicinal chemistry and materials science. Its orthogonal halogenation pattern enables selective cross-coupling reactions, including Pd-catalyzed Suzuki and Negishi couplings. The carboxylic acid group facilitates direct amidation or esterification, supporting rapid diversification. The compound exhibits excellent bench stability and is readily purified by recrystallization, making it well-suited for high-throughput synthetic workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501
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Lot numbers can be found on the outside label of a product: