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CS-W001157 4
Total: USD 88.00

4-Cyclopropyl-1H-pyrazole

  • CAS No. 90253-21-7

  • Cat. No. CS-0136307
  • Purity≥98%
  • MDL No.MFCD22681810

*For research and further manufacturing use only, not for direct human use.

4-Cyclopropyl-1H-pyrazole|CS-0136307

Structure of 90253-21-7

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General Information

  • CAS No. 90253-21-7
  • Cat. No. CS-0136307
  • Purity ≥98%
  • MDL No. MFCD22681810
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂
  • Molecular Weight 108.14
  • Synonym(s) 4-Cyclopropylpyrazol
  • SMILES C1(C2CC2)=CNN=C1

Description

4-Cyclopropyl-1H-pyrazole features a cyclopropyl group at the 4-position of the pyrazole ring, imparting enhanced lipophilicity and metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key pharmacophore in medicinal chemistry. The strained cyclopropyl moiety contributes to conformational rigidity, improving target binding affinity.

Application

4-Cyclopropyl-1H-pyrazole serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of diverse scaffolds through standard functionalization at the 1- and 3-positions. Its cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, offering favorable physicochemical properties for drug discovery. The pyrazole core exhibits robust bench stability, compatibility with common coupling reactions, and ease of purification—making it a practical choice for high-throughput synthesis and API development.

Synthesis

  • Route1
    • null|null
      51007-72-8
    • ~74%
    • In-stock
      4-Cyclopropyl-1H-pyrazole|CS-0136307
      90253-21-7

    References

    • Reichardt, Christian; Ferwanah, Abdel-Rahman; Pressler, Wilfried; Yun, Kyeong-Yeol Liebigs Annalen der Chemie, 1984 , # 4 p. 649 - 679
  • Route2
    • (2-Methoxy-vinyl)-cyclopropane|CS-0341239
      73686-07-4
    • ~%
    • In-stock
      4-Cyclopropyl-1H-pyrazole|CS-0136307
      90253-21-7

    References

    • Reichardt, Christian; Ferwanah, Abdel-Rahman; Pressler, Wilfried; Yun, Kyeong-Yeol Liebigs Annalen der Chemie, 1984 , # 4 p. 649 - 679

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.2871
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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