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CS-W001157 4
Total: USD 88.00

2-(6-Methoxypyridin-3-yl)acetic acid

  • CAS No. 902130-87-4

  • Cat. No. CS-0082326
  • Purity≥95%
  • MDL No.MFCD09924951

*For research and further manufacturing use only, not for direct human use.

2-(6-Methoxypyridin-3-yl)acetic acid|CS-0082326

Structure of 902130-87-4

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General Information

  • CAS No. 902130-87-4
  • Cat. No. CS-0082326
  • Purity ≥95%
  • MDL No. MFCD09924951
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₃
  • Molecular Weight None
  • Synonym(s) 6-Methoxy-3-pyridineacetic acid
  • SMILES COC1=CC=C(CC(O)=O)C=N1

Description

2-(6-Methoxypyridin-3-yl)acetic acid features a pyridine core functionalized with a methoxy group at the 6-position and a carboxylic acid-bearing acetyl side chain at the 3-position. This structure integrates a polar, electron-rich heterocycle with a reactive handle for conjugation or derivatization. The compound exhibits enhanced solubility and stability under standard bench conditions, enabling straightforward incorporation into synthetic routes targeting bioactive molecules and pharmaceutical intermediates.

Application

2-(6-Methoxypyridin-3-yl)acetic acid serves as a versatile building block for constructing bioactive heterocycles and pharmaceutical intermediates. Its pyridine core enables facile functionalization, while the carboxylic acid group facilitates coupling reactions, esterification, or amide formation under standard conditions. The molecule exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for multi-step synthesis in medicinal chemistry workflows.

Synthesis

  • Route1
    • Diethyl 2-(6-methoxypyridin-3-yl)malonate|CS-0467051
      902130-84-1
    • ~70%
    • In-stock
      2-(6-Methoxypyridin-3-yl)acetic acid|CS-0082326
      902130-87-4

    References

    • Zhang, Xuqing; Sui, Zhihua Synthesis, 2006 , # 15 p. 2568 - 2572
  • Route2

    References

    • WO2007/75567 A1, ; Page/Page column 93 ; WO 2007/075567 A1
  • Route3

    References

    • Synthesis, , # 15 p. 2568 - 2572

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   0.7173
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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