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CS-W001157 4
Total: USD 88.00

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl) methyl]thiophene

  • CAS No. 898566-17-1

  • Cat. No. CS-M1890
  • Purity≥98%
  • MDL No.MFCD12405593

*For research and further manufacturing use only, not for direct human use.

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl) methyl]thiophene|CS-M1890

Structure of 898566-17-1

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General Information

  • CAS No. 898566-17-1
  • Cat. No. CS-M1890
  • Purity ≥98%
  • MDL No. MFCD12405593
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₁₄FIS
  • Molecular Weight 408.27
  • Synonym(s) None
  • SMILES CC1=C(CC2=CC=C(C3=CC=C(F)C=C3)S2)C=C(I)C=C1

Description

This thiophene derivative features a 4-fluorophenyl group and a 5-iodo-2-methylphenylmethyl substituent, enabling efficient coupling in cross-coupling reactions. The electron-deficient thiophene core enhances reactivity in palladium-catalyzed transformations, while the iodine handle facilitates selective functionalization. Designed for synthetic precision in pharmaceutical and materials chemistry applications.

Application

2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl architectures. The iodine substituent provides high reactivity under palladium catalysis, while the thiophene core offers stability and compatibility with diverse functional groups. Its bench-stable nature and straightforward purification facilitate integration into complex synthetic sequences for pharmaceutical and materials applications.

Synthesis

  • Route1
    • 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl]thiophene Canagliflozin Impurity|CS-0213940
      1030825-20-7
    • ~%
    • In-stock
      2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl) methyl]thiophene|CS-M1890
      898566-17-1

    References

    • WO2009/35969 A1, ; Page/Page column 77 ; WO 2009/035969 A1
  • Route2
    • In-stock
      2-(4-Fluorophenyl)thiophene|CS-M2131
      58861-48-6
    • null|null
      108440-70-6
    • ~%
    • In-stock
      2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl) methyl]thiophene|CS-M1890
      898566-17-1

    References

    • US2010/99883 A1, ; Page/Page column 40-41 ; US 20100099883 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   6.05802
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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