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CS-W001157 4
Total: USD 88.00

4-Chloro-6-ethoxy-2-pyrimidinamine

  • CAS No. 89784-02-1

  • Cat. No. CS-0312809
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-ethoxy-2-pyrimidinamine|CS-0312809

Structure of 89784-02-1

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Description

4-Chloro-6-ethoxy-2-pyrimidinamine serves as a key heterocyclic scaffold in medicinal chemistry, featuring a chlorine atom at C4 and an ethoxy group at C6. This electron-deficient pyrimidine core enables efficient coupling reactions and facilitates incorporation into bioactive molecules, particularly in kinase inhibitor design and antiviral agents. The compound exhibits bench-stable handling under standard conditions.

Application

4-Chloro-6-ethoxy-2-pyrimidinamine serves as a versatile building block in medicinal chemistry, enabling the construction of pyrimidine-based scaffolds via nucleophilic substitution and palladium-catalyzed coupling reactions. Its chlorine and amine functionalities offer orthogonal reactivity for sequential derivatization, while the ethoxy group enhances solubility and modulates electronic properties. Bench-stable and readily purified by chromatography, it facilitates efficient synthesis of kinase inhibitors and other bioactive heterocycles.

General Information

  • CAS No. 89784-02-1
  • Cat. No. CS-0312809
  • Purity ≥95%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈ClN₃O
  • Molecular Weight 173.60
  • Synonym(s) 4-Chloro-6-ethoxypyrimidin-2-amine
  • SMILES NC1=NC(OCC)=CC(Cl)=N1

Computational Chemistry Data

  • TPSA   61.03
  • LogP   1.1109
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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