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CS-W001157 4
Total: USD 88.00

Methyl 6-hydroxypyridazine-4-carboxylate

  • CAS No. 89640-81-3

  • Cat. No. CS-0061835
  • Molecule weight154.12
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Methyl 6-hydroxypyridazine-4-carboxylate|CS-0061835

Structure of 89640-81-3

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General Information

  • CAS No. 89640-81-3
  • Cat. No. CS-0061835
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆N₂O₃
  • Molecular Weight 154.12
  • Synonym(s) Methyl 6-oxo-1,6-dihydropyridazine-4-carboxylate
  • SMILES COC(=O)C1=CC(=NN=C1)O

Description

Methyl 6-hydroxypyridazine-4-carboxylate features a pyridazine core bearing both hydroxyl and ester functionalities, enabling direct functionalization at the 6-position. This bench-stable derivative serves as a key intermediate in heterocyclic synthesis, particularly for bioactive molecule development. The electron-deficient ring facilitates nucleophilic substitution, while the hydroxyl group offers a handle for derivatization under mild conditions.

Application

Methyl 6-hydroxypyridazine-4-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridazine-based heterocycles. The hydroxyl group facilitates direct functionalization or protection, while the ester moiety supports selective transformations and downstream derivatization. Its bench-stable nature and compatibility with standard coupling and reduction protocols make it ideal for modular synthesis of bioactive scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.31
  • LogP   -0.0312
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   1

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