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CS-W001157 4
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(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylbutanoic acid

  • CAS No. 89536-85-6

  • Cat. No. CS-0041825
  • Purity≥97%
  • MDL No.MFCD00076996

*For research and further manufacturing use only, not for direct human use.

(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylbutanoic acid|CS-0041825

Structure of 89536-85-6

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General Information

  • CAS No. 89536-85-6
  • Cat. No. CS-0041825
  • Purity ≥97%
  • MDL No. MFCD00076996
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₁NO₄
  • Molecular Weight 231.29
  • Synonym(s) None
  • SMILES CC(C)[C@@H](N(C)C(=O)OC(C)(C)C)C(O)=O

Description

(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylbutanoic acid is a chiral building block featuring a stereodefined (R)-center and a protected amine. This bench-stable derivative integrates seamlessly into peptide synthesis workflows, where the tert-butoxycarbonyl group enables selective N-terminal protection. The methyl-substituted aliphatic chain enhances solubility in organic solvents, supporting efficient coupling reactions under standard conditions.

Application

(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-3-methylbutanoic acid serves as a versatile chiral building block for peptide synthesis and medicinal chemistry applications. Its tert-butyl carbamate (Boc) group enables orthogonal protection of primary amines, while the methylamino functionality provides a handle for further derivatization. The molecule exhibits excellent bench stability, facilitates straightforward purification via standard chromatographic methods, and participates reliably in amide coupling and reduction reactions within established synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.9625
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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