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CS-W001157 4
Total: USD 88.00

3-(1H-Pyrazol-1-yl)propanoic acid

  • CAS No. 89532-73-0

  • Cat. No. CS-W004012
  • Purity≥97%
  • MDL No.MFCD01822327

*For research and further manufacturing use only, not for direct human use.

3-(1H-Pyrazol-1-yl)propanoic acid|CS-W004012

Structure of 89532-73-0

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General Information

  • CAS No. 89532-73-0
  • Cat. No. CS-W004012
  • Purity ≥97%
  • MDL No. MFCD01822327
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O₂
  • Molecular Weight 140.14
  • Synonym(s) Albb-004381
  • SMILES OC(=O)CCn1cccn1

Description

3-(1H-Pyrazol-1-yl)propanoic acid integrates a pyrazole ring with a flexible propionic acid tether, enabling precise conjugation in bioactive molecule design. This scaffold delivers enhanced solubility and metabolic stability while maintaining strong hydrogen-bonding capacity for target engagement.

Application

3-(1H-Pyrazol-1-yl)propanoic acid serves as a versatile building block for medicinal chemistry and synthetic organic applications. Its pyrazole moiety enables hydrogen bonding and π–π interactions, while the aliphatic carboxylic acid facilitates derivatization via amide coupling, esterification, or metal complexation. The compound exhibits good bench stability and functional group tolerance, making it suitable for modular synthesis of bioactive heterocycles and pharmaceutical intermediates.

Synthesis

  • Route1
    • null|null
      623-71-2
    • ~%
    • In-stock
      3-(1H-Pyrazol-1-yl)propanoic acid|CS-W004012
      89532-73-0

    References

    • US5972064 A1, ;
  • Route2
    • null|null
      79-10-7
    • ~%
    • In-stock
      3-(1H-Pyrazol-1-yl)propanoic acid|CS-W004012
      89532-73-0

    References

    • US6162927 A1, ; US 6162927 A
  • Route3
    • Ethyl 3-(1h-pyrazol-1-yl)propanoate|CS-0673179
      853270-73-2
    • ~%
    • In-stock
      3-(1H-Pyrazol-1-yl)propanoic acid|CS-W004012
      89532-73-0

    References

    • Synlett, , vol. 1997, # 8 p. 1013 - 1014

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   0.3578
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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