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CS-W001157 4
Total: USD 88.00

2-Bromo-4-methoxypyridine

  • CAS No. 89488-29-9

  • Cat. No. CS-D1649
  • Purity≥96%
  • MDL No.MFCD06254613

*For research and further manufacturing use only, not for direct human use.

2-Bromo-4-methoxypyridine|CS-D1649

Structure of 89488-29-9

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General Information

  • CAS No. 89488-29-9
  • Cat. No. CS-D1649
  • Purity ≥96%
  • MDL No. MFCD06254613
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrNO
  • Molecular Weight 188.02
  • Synonym(s) None
  • SMILES COC1=CC(Br)=NC=C1

Description

2-Bromo-4-methoxypyridine is a halogenated pyridine derivative featuring a bromine atom at the 2-position and a methoxy group at the 4-position. This combination imparts enhanced electrophilicity and regioselective reactivity in cross-coupling transformations. The molecule exhibits favorable stability under standard conditions, enabling reliable incorporation into diverse synthetic sequences.

Application

2-Bromo-4-methoxypyridine serves as a versatile building block in medicinal chemistry and cross-coupling synthesis. Its bromine moiety enables reliable Suzuki, Stille, and Negishi coupling reactions, while the 4-methoxy group enhances solubility and modulates electronic properties. The compound exhibits excellent bench stability and is compatible with a range of functional groups, facilitating efficient construction of substituted pyridine scaffolds in API development.

Synthesis

  • Route1
    • null|null
      124-41-4
    • In-stock
      2-Bromo-4-chloropyridine|CS-W003129
      22918-01-0
    • ~25%
    • In-stock
      2-Bromo-4-methoxypyridine|CS-D1649
      89488-29-9

    References

    • WO2014/74422 A1, ; Paragraph 00162 ;
  • Route2
    • In-stock
      2-Bromo-4-hydroxypyridine|CS-W004923
      36953-40-9
    • null|null
      74-88-4
    • ~23%
    • In-stock
      2-Bromo-4-methoxypyridine|CS-D1649
      89488-29-9

    References

    • European Journal of Inorganic Chemistry, , # 19 p. 3334 - 3347

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.8527
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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