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Structure of 89226-12-0
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S-tert-Leucine N-methylamide features a sterically hindered side chain and a stable N-methylamide terminus, enabling enhanced metabolic resistance and improved membrane permeability. This configuration supports efficient incorporation into peptide sequences under standard conditions, offering robust stability in bioactive peptide synthesis workflows.
S-tert-Leucine N-methylamide serves as a valuable chiral building block in peptide synthesis, offering enhanced metabolic stability and improved membrane permeability compared to its parent amino acid. The N-methylated amide functionality reduces hydrogen bonding capacity while maintaining backbone conformational rigidity, facilitating incorporation into bioactive peptides. Its tert-leucine side chain provides steric bulk that can modulate proteolytic resistance and target binding affinity, making it particularly useful in medicinal chemistry campaigns targeting peptidomimetics and macrocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Lot numbers can be found on the outside label of a product: