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CS-W001157 4
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4-Fluoro-7-methyl-1H-indole-2-carboxylic acid

  • CAS No. 891724-25-7

  • Cat. No. CS-0144147
  • Molecule weight193.17
  • Purity≥98%
  • MDL No.MFCD05170462

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-7-methyl-1H-indole-2-carboxylic acid|CS-0144147

Structure of 891724-25-7

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General Information

  • CAS No. 891724-25-7
  • Cat. No. CS-0144147
  • Purity ≥98%
  • MDL No. MFCD05170462
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈FNO₂
  • Molecular Weight 193.17
  • Synonym(s) None
  • SMILES O=C(C(N1)=CC2=C1C(C)=CC=C2F)O

Description

4-Fluoro-7-methyl-1H-indole-2-carboxylic acid features a fluorinated indole core with a methyl group at the 7-position and a carboxylic acid at C2, delivering enhanced metabolic stability and tunable solubility. This scaffold integrates readily into bioactive molecules, enabling efficient access to functionalized heterocycles in medicinal chemistry applications.

Application

4-Fluoro-7-methyl-1H-indole-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of indole-based scaffolds prevalent in kinase inhibitors and CNS-targeted therapeutics. The carboxylic acid group facilitates direct coupling reactions, while the 4-fluoro and 7-methyl substituents provide orthogonal functional handles for further derivatization. Its bench-stable nature and compatibility with standard peptide coupling protocols enhance utility in multi-step syntheses.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   53.09
  • LogP   2.31362
  • H_Acceptors   1
  • H_Donors   2
  • Rotatable_Bonds   1

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