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CS-W001157 4
Total: USD 88.00

(2-Chlorophenyl)methanamine

  • CAS No. 89-97-4

  • Cat. No. CS-W016433
  • Molecule weight141.60
  • Purity≥98%
  • MDL No.MFCD00008108

*For research and further manufacturing use only, not for direct human use.

(2-Chlorophenyl)methanamine|CS-W016433

Structure of 89-97-4

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General Information

  • CAS No. 89-97-4
  • Cat. No. CS-W016433
  • Purity ≥98%
  • MDL No. MFCD00008108
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈ClN
  • Molecular Weight 141.60
  • Synonym(s) 2-Chlorobenzylamine
  • SMILES NCC1=CC=CC=C1Cl

Description

(2-Chlorophenyl)methanamine is a bench-stable arylalkyl amine featuring a chlorinated phenyl ring directly linked to a primary amine group. This structural motif enables direct incorporation into pharmaceutical intermediates and functional materials, where the electron-withdrawing chlorine enhances reactivity in electrophilic substitution processes.

Application

(2-Chlorophenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-chloro substituent provides enhanced metabolic stability and modulates electronic properties, while the primary amine facilitates straightforward derivatization via coupling, acylation, or reductive amination. The compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for scalable synthesis and process development.

Synthesis

  • Route1
    • null|null
      63777-70-8
    • ~88%
    • In-stock
      (2-Chlorophenyl)methanamine|CS-W016433
      89-97-4

    References

    • Tetrahedron Letters, , vol. 44, # 1 p. 171 - 174
  • Route2

    References

    • US5210303 A1, ;
  • Route3
    • null|null
      611-19-8
    • ~86%
    • In-stock
      (2-Chlorophenyl)methanamine|CS-W016433
      89-97-4

    References

    • US5210303 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅱ
Hazard Statements : H227-H314
Precautionary Statements : P210-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.7987
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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