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CS-W001157 4
Total: USD 88.00

4-Chlorophthalic acid

  • CAS No. 89-20-3

  • Cat. No. CS-0101178
  • Purity≥97%
  • MDL No.MFCD00044755

*For research and further manufacturing use only, not for direct human use.

4-Chlorophthalic acid|CS-0101178

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General Information

  • CAS No. 89-20-3
  • Cat. No. CS-0101178
  • Purity ≥97%
  • MDL No. MFCD00044755
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClO₄
  • Molecular Weight 200.58
  • Synonym(s) Phthalic acid, 4-chloro-
  • SMILES O=C(C1=CC=C(Cl)C=C1C(O)=O)O

Description

4-Chlorophthalic acid is a bench-stable, electron-deficient aromatic diacid featuring a chlorine substituent at the para position relative to one carboxyl group. This structural motif enables selective coupling reactions in polymer synthesis and coordination chemistry, where its dual functionality integrates seamlessly into rigid, functional architectures under standard conditions.

Application

4-Chlorophthalic acid serves as a versatile building block in synthetic organic chemistry, enabling the construction of phthalimide derivatives and heterocyclic scaffolds through standard amide formation and cyclization reactions. Its ortho-dicarboxylic acid functionality offers high reactivity in coupling processes, while the chloro substituent provides a handle for subsequent nucleophilic aromatic substitution. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry and materials synthesis workflows.

Synthesis

  • Route1

    References

    • Occidental Chemical Corporation Patent: US4981999 A1, 1991 ;
  • Route2

    References

    • US4025505 A1, ;
  • Route3

    References

    • US3965125 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   74.6
  • LogP   1.7364
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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