4-Bromo-1-(difluoromethoxy)-2-methylbenzene

Name: 4-Bromo-1-(difluoromethoxy)-2-methylbenzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 888327-32-0
Cat. No. CS-0041686
Molecule weight237.04
Purity≥98%
MDL No.MFCD11036069

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Bromo-1-(difluoromethoxy)-2-methylbenzene|CS-0041686

Structure of 888327-32-0

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 888327-32-0
Cat. No. CS-0041686
Purity ≥98%
MDL No. MFCD11036069
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₇BrF₂O
Molecular Weight 237.04
Synonym(s) 5-Bromo-2-(difluoromethoxy)toluene
SMILES CC1=CC(Br)=CC=C1OC(F)F

Description

This difluoromethoxy-substituted aryl bromide enables direct coupling in cross-coupling reactions, offering enhanced stability and selective reactivity. The electron-withdrawing fluorine atoms improve functional group tolerance, while the methyl group provides steric control. Ideal for constructing complex aromatic architectures under standard conditions.

Application

4-Bromo-1-(difluoromethoxy)-2-methylbenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura and Stille couplings. The difluoromethoxy group imparts metabolic stability and modulates lipophilicity, while the bromo and methyl substituents provide orthogonal reactivity and steric control. Its bench-stable nature and compatibility with standard synthetic workflows make it ideal for constructing complex aromatic scaffolds in API development.

Synthesis

Route1
- In-stock
  
  83190-02-7
- ~38%
- In-stock
  
  888327-32-0
References
- KALYSPSYS, INC.; NOBLE, Stewart A.; OSHIRO, Guy; MALECHA, James W.; ZHAO, Cunxiang; ROBINSON, Carmen K. M.; DURON, Sergio G.; SERTIC, Michael; LINDSTROM, Andrew; SHIAU, Andrew; BAYNE, Christopher; KAHRAMAN, Mehmet; LOU, Boliang; GOVEK, Steven Patent: WO2006/55187 A1, 2006 ; Location in patent: Page/Page column 83 ; WO 2006/055187 A1
Route2
- In-stock
  
  2362-12-1
- In-stock
  
  1895-39-2
- ~18%
- In-stock
  
  888327-32-0
References
- WYETH Patent: WO2008/115552 A1, 2008 ; Location in patent: Page/Page column 72 ; WO 2008/115552 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 9.23
LogP 3.35892
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

888327-32-0 sigma888327-32-0 manufacturer888327-32-0 price888327-32-0 structure888327-32-0 SDSbuy 888327-32-0888327-32-0 supplier888327-32-0 uses888327-32-0 molecular weightprice of 888327-32-0888327-32-0 chemical name formula of 888327-32-0

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Bromo-1-(difluoromethoxy)-2-methylbenzene

CAS No. 888327-32-0

Recommended Products