Lot numbers can be found on the outside label of a product:
3-Isopropylisoxazol-5-amine
-
CAS No. 88786-11-2
- Cat. No. CS-W021950
- Purity≥98%
- MDL No.MFCD06335179
*For research and further manufacturing use only, not for direct human use.
Structure of 88786-11-2
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 88786-11-2
- Cat. No. CS-W021950
- Purity ≥98%
- MDL No. MFCD06335179
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₁₀N₂O
- Molecular Weight 126.16
- Synonym(s) 3-Isopropyl-1,2-oxazol-5-amine
- SMILES NC1=CC(C(C)C)=NO1
Description
3-Isopropylisoxazol-5-amine is a bench-stable, moisture-tolerant heterocyclic amine featuring a sterically hindered isopropyl group at the 3-position. This substitution enhances solubility in organic solvents while maintaining reactivity at the nitrogen-bearing isoxazole ring. The compound serves as a versatile scaffold for medicinal chemistry applications, particularly in the development of kinase inhibitors and CNS-targeted therapeutics.
Application
3-Isopropylisoxazol-5-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of bioactive molecules through standard functional group transformations. Its isoxazole core provides structural rigidity and metabolic stability, while the primary amine facilitates conjugation reactions. The compound exhibits excellent bench stability, ease of purification, and compatibility with diverse coupling protocols, making it well-suited for iterative synthesis campaigns and API development workflows.
Synthesis
-
Route1
-
In-stock
29509-06-6 - ~77%
-
In-stock
88786-11-2
References
-
Rowbottom, Martin W.; Faraoni, Raffaella; Chao, Qi; Campbell, Brian T.; Lai, Andiliy G.; Setti, Eduardo; Ezawa, Maiko; Sprankle, Kelly G.; Abraham, Sunny; Tran, Lan; Struss, Brian; Gibney, Michael; Armstrong, Robert C.; Gunawardane, Ruwanthi N.; Nepomuceno, Ronald R.; Valenta, Ianina; Hua, Helen; Gardner, Michael F.; Cramer, Merryl D.; Gitnick, Dana; Insko, Darren E.; Apuy, Julius L.; Jones-Bolin, Susan; Ghose, Arup K.; Herbertz, Torsten; Ator, Mark A.; Dorsey, Bruce D.; Ruggeri, Bruce; Williams, Michael; Bhagwat, Shripad; James, Joyce; Holladay, Mark W. Journal of Medicinal Chemistry, 2012 , vol. 55, # 3 p. 1082 - 1105
-
-
Route2
-
In-stock
64373-43-9 - ~%
-
In-stock
88786-11-2
References
-
WO2010/66684 A2, ; Page/Page column 58-59 ; WO 2010/066684 A2
-
-
Route3
-
2861-04-3 - ~87%
-
In-stock
88786-11-2
References
-
Fomum, Z. Tanee; Asobo, P. Forsche; Landor, Stephen R.; Landor, Phyllis D. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 5 p. 1079 - 1083
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 52.05
- LogP 1.3802
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 3-Isopropylisoxazol-5-amine sigma3-Isopropylisoxazol-5-amine manufacturer3-Isopropylisoxazol-5-amine price3-Isopropylisoxazol-5-amine structure3-Isopropylisoxazol-5-amine SDSbuy 3-Isopropylisoxazol-5-amine3-Isopropylisoxazol-5-amine supplier3-Isopropylisoxazol-5-amine uses3-Isopropylisoxazol-5-amine molecular weightprice of 3-Isopropylisoxazol-5-amine3-Isopropylisoxazol-5-amine chemical name formula of 3-Isopropylisoxazol-5-amine