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CS-W001157 4
Total: USD 88.00

6-bromo-2,3-difluoroaniline

  • CAS No. 887579-74-0

  • Cat. No. CS-0067562
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-bromo-2,3-difluoroaniline|CS-0067562

Structure of 887579-74-0

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General Information

  • CAS No. 887579-74-0
  • Cat. No. CS-0067562
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrF₂N
  • Molecular Weight 208.00
  • Synonym(s) 2-AMino-3,4-difluorobroMobenznee[6-BroMo-2,3-difluoroaniline]
  • SMILES NC1=C(Br)C=CC(F)=C1F

Description

6-Bromo-2,3-difluoroaniline features a strategically positioned bromine atom and two fluorine substituents that enhance electron deficiency and direct electrophilic substitution. This aryl amine integrates readily into pharmaceutical intermediates, offering high reactivity under standard coupling conditions with minimal side reactions.

Application

6-Bromo-2,3-difluoroaniline serves as a valuable building block for pharmaceutical and agrochemical synthesis, enabling direct incorporation of bromo and difluoro substituents in heterocyclic scaffolds. Its ortho-fluorine substitution enhances metabolic stability and modulates electronic properties, while the amino group facilitates Suzuki-Miyaura and Buchwald-Hartwig couplings. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthetic sequences in medicinal chemistry.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.3095
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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