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CS-W001157 4
Total: USD 88.00

6-(Trifluoromethyl)-1H-indazole-3-carboxylic acid

  • CAS No. 887576-98-9

  • Cat. No. CS-0187178
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethyl)-1H-indazole-3-carboxylic acid|CS-0187178

Structure of 887576-98-9

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General Information

  • CAS No. 887576-98-9
  • Cat. No. CS-0187178
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₅F₃N₂O₂
  • Molecular Weight 230.14
  • Synonym(s) 1H-Indazole-3-carboxylic acid,6-(trifluoromethyl)
  • SMILES C1=CC2=C(C=C1C(F)(F)F)NN=C2C(=O)O

Description

6-(Trifluoromethyl)-1H-indazole-3-carboxylic acid features a trifluoromethyl group at the 6-position and a carboxylic acid at the 3-position, conferring enhanced electron-withdrawing character and improved solubility in polar solvents. This scaffold integrates readily into bioactive molecules, particularly in kinase inhibitors and drug candidates requiring high metabolic stability and favorable pharmacokinetic profiles.

Application

6-(Trifluoromethyl)-1H-indazole-3-carboxylic acid serves as a versatile building block for medicinal chemistry campaigns, enabling the construction of bioactive heterocycles through standard amide coupling and derivatization protocols. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid functionality facilitates direct conjugation or salt formation. Bench-stable and compatible with common purification methods, it functions reliably in both small-molecule synthesis and high-throughput screening workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   2.2799
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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