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Structure of 886762-39-6
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3,4-Dichloro-2-fluoroaniline features a fluorine atom at the ortho position relative to the amino group, enhancing electron withdrawal and metabolic stability. The adjacent dichloro substitution provides strong electron-withdrawing character, enabling selective coupling in pharmaceutical intermediates. This aromatic amine integrates readily into complex heterocycles under standard conditions, offering high reactivity with minimal side-product formation.
3,4-Dichloro-2-fluoroaniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering orthogonal reactivity through its complementary halogenation pattern. The molecule enables direct coupling reactions via palladium-catalyzed cross-coupling protocols, while the fluorine and chlorine substituents provide enhanced metabolic stability and modulated electronic properties. Bench-stable and readily purified by recrystallization, it functions as a versatile scaffold for constructing complex heterocyclic systems and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: