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CS-W001157 4
Total: USD 88.00

3,4-Dichloro-2-fluoroaniline

  • CAS No. 886762-39-6

  • Cat. No. CS-W006195
  • Purity≥96%
  • MDL No.MFCD04039241
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3,4-Dichloro-2-fluoroaniline|CS-W006195

Structure of 886762-39-6

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Description

3,4-Dichloro-2-fluoroaniline features a fluorine atom at the ortho position relative to the amino group, enhancing electron withdrawal and metabolic stability. The adjacent dichloro substitution provides strong electron-withdrawing character, enabling selective coupling in pharmaceutical intermediates. This aromatic amine integrates readily into complex heterocycles under standard conditions, offering high reactivity with minimal side-product formation.

Application

3,4-Dichloro-2-fluoroaniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering orthogonal reactivity through its complementary halogenation pattern. The molecule enables direct coupling reactions via palladium-catalyzed cross-coupling protocols, while the fluorine and chlorine substituents provide enhanced metabolic stability and modulated electronic properties. Bench-stable and readily purified by recrystallization, it functions as a versatile scaffold for constructing complex heterocyclic systems and API intermediates.

General Information

  • CAS No. 886762-39-6
  • Cat. No. CS-W006195
  • Purity ≥96%
  • MDL No. MFCD04039241
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Cl₂FN
  • Molecular Weight 180.01
  • Synonym(s) 2-Fluoro-3,4-Dichloroaniline
  • SMILES NC1=CC=C(Cl)C(Cl)=C1F

Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.7147
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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