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CS-W001157 4
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2-Bromo-1-(4-fluorophenyl)-2-phenylethan-1-one

  • CAS No. 88675-31-4

  • Cat. No. CS-0199675
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Bromo-1-(4-fluorophenyl)-2-phenylethan-1-one|CS-0199675

Structure of 88675-31-4

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General Information

  • CAS No. 88675-31-4
  • Cat. No. CS-0199675
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₀BrFO
  • Molecular Weight 293.13
  • Synonym(s) 2-Bromo-1-(4-fluorophenyl)-2-phenylethanone
  • SMILES C1=CC=C(C=C1)C(C(=O)C2=CC=C(C=C2)F)Br

Description

This bromoketone features a fluorophenyl moiety flanked by a phenyl group and a reactive carbonyl, enabling direct functionalization in cross-coupling processes. The electron-deficient aryl system enhances reactivity, while the bromine atom provides a handle for palladium-catalyzed transformations. Bench-stable under standard conditions, it integrates efficiently into complex molecular architectures.

Application

2-Bromo-1-(4-fluorophenyl)-2-phenylethan-1-one serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. Its brominated ketone functionality supports palladium-catalyzed cross-coupling reactions, while the fluorophenyl and phenyl groups provide orthogonal reactivity and structural rigidity. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • VIJAYASRI ORGANICS LIMITED; SRIVATSAVAYI, Jagapathi Raju; POTHUKUCHI, Sairam; RANI, Srinivasa Sastry; CHIKKA, Mallikarjuna Rao; CHEEKATI, Chiranjeevi; GUTTI, Mallikarjuna Rao; SINGAVARAPU, Trimurthulu; THIMMAIPALLY , Venkat Reddy; TADANKI, Venkateswara Rao Patent: WO2012/143933 A1, 2012 ; Location in patent: Page/Page column 13-14 ;
  • Route2
    • null|null
      462-06-6
    • ~%
    • In-stock
      2-Bromo-1-(4-fluorophenyl)-2-phenylethan-1-one|CS-0199675
      88675-31-4

    References

    • WO2012/143933 A1, ;
  • Route3
    • null|null
      103-80-0
    • ~%
    • In-stock
      2-Bromo-1-(4-fluorophenyl)-2-phenylethan-1-one|CS-0199675
      88675-31-4

    References

    • WO2012/143933 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   4.1446
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   3

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