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Structure of 886497-85-4
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2-Fluoro-5-(trifluoromethoxy)benzoic acid features a strategically positioned trifluoromethoxy group that enhances lipophilicity and metabolic stability. This electron-withdrawing substituent, combined with the fluorine atom at the ortho position, imparts strong acidity and directional reactivity. The compound serves as a valuable building block in medicinal chemistry, particularly for developing bioactive molecules where controlled solubility and target engagement are critical.
2-Fluoro-5-(trifluoromethoxy)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical scaffolds. Its orthogonal functional groups—fluorine, trifluoromethoxy, and carboxylic acid—offer enhanced metabolic stability and modulated lipophilicity. The compound exhibits robust bench stability, facilitates straightforward derivatization via amide or ester formation, and is compatible with standard coupling reactions, making it a reliable component in API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: