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CS-W001157 4
Total: USD 88.00

6-(Bromomethyl)-2-chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine

  • CAS No. 885698-98-6

  • Cat. No. CS-0006871
  • Molecule weight348.65
  • Purity95+%
  • MDL No.MFCD13190351

*For research and further manufacturing use only, not for direct human use.

6-(Bromomethyl)-2-chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine|CS-0006871

Structure of 885698-98-6

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General Information

  • CAS No. 885698-98-6
  • Cat. No. CS-0006871
  • Purity 95+%
  • MDL No. MFCD13190351
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁BrClN₃OS
  • Molecular Weight 348.65
  • Synonym(s) 4-(6-(Bromomethyl)-2-chlorothieno[3,2-d]pyrimidin-4-yl)morpholine
  • SMILES ClC1=NC2=C(SC(CBr)=C2)C(N3CCOCC3)=N1

Synthesis

  • Route1
    • (2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanol|CS-M0481
      885698-97-5
    • ~96%
    • 6-(Bromomethyl)-2-chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine|CS-0006871
      885698-98-6

    References

    • GENENTECH, INC.; PIRAMED LIMITED; CASTANEDO, Georgette; DOTSON, Jennafer; GOLDSMITH, Richard; GUNZNER, Janet; HEFFRON, Tim; MATHIEU, Simon; OLIVERO, Alan; STABEN, Steven; SUTHERLIN, Daniel P.; TSUI, Vickie; WANG, Shumei; ZHU, Bing-Yan; BAYLISS, Tracy; CHUCKOWREE, Irina; FOLKES, Adrian; WAN, Nan Chi Patent: WO2008/73785 A2, 2008 ; Location in patent: Page/Page column 161 ; WO 2008/073785 A2
  • Route2

    References

    • CURIS, INC.; BAO, Rudi; LAI, Chengjung; QIAN, Changgeng Patent: WO2011/130628 A1, 2011 ; WO 2011/130628 A1
  • Route3
    • 4-{2-Chlorothieno[3,2-d]pyrimidin-4-yl}morpholine|CS-B0059
      16234-15-4
    • ~%
    • 6-(Bromomethyl)-2-chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine|CS-0006871
      885698-98-6

    References

    • CURIS, INC.; BAO, Rudi; LAI, Chengjung; QIAN, Changgeng Patent: WO2011/130628 A1, 2011 ; WO 2011/130628 A1

Safety Information

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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   38.25
  • LogP   3.0762
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   2

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