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CS-W001157 4
Total: USD 88.00

6-Bromo-1H-indazole-4-carboxylic acid

  • CAS No. 885523-08-0

  • Cat. No. CS-W003374
  • Purity≥98%
  • MDL No.MFCD07368215

*For research and further manufacturing use only, not for direct human use.

6-Bromo-1H-indazole-4-carboxylic acid|CS-W003374

Structure of 885523-08-0

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General Information

  • CAS No. 885523-08-0
  • Cat. No. CS-W003374
  • Purity ≥98%
  • MDL No. MFCD07368215
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrN₂O₂
  • Molecular Weight 241.04
  • Synonym(s) 6-BROMO-(1H)INDAZOLE-4-CARBOXYLIC ACID
  • SMILES Brc1cc(C(=O)O)c2c(c1)[nH]nc2

Description

6-Bromo-1H-indazole-4-carboxylic acid features a brominated indazole core with a carboxylic acid group at the 4-position, enabling direct conjugation in medicinal chemistry. This electron-deficient scaffold integrates readily into bioactive molecules, offering enhanced metabolic stability and targeted binding potential in kinase inhibitor design.

Application

6-Bromo-1H-indazole-4-carboxylic acid serves as a versatile building block for the synthesis of indazole-based pharmaceuticals and agrochemicals. Its bromo group enables palladium-catalyzed cross-coupling reactions, while the carboxylic acid functionality facilitates derivatization via amide formation or esterification. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318-H412
Precautionary Statements : P273-P280-P501

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   2.0236
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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