6-Fluoro-1H-benzo[d]imidazole-2-carbaldehyde

Name: 6-Fluoro-1H-benzo[d]imidazole-2-carbaldehyde
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CAS No. 885280-34-2
Cat. No. CS-0043844
Purity≥96%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Fluoro-1H-benzo[d]imidazole-2-carbaldehyde|CS-0043844

Structure of 885280-34-2

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General Information

CAS No. 885280-34-2
Cat. No. CS-0043844
Purity ≥96%
MDL No. None
Storage -20°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅FN₂O
Molecular Weight 164.14
Synonym(s) 6-fluoro-1H-1,3-benzodiazole-2-carbaldehyde
SMILES O=CC1=NC2=CC=C(F)C=C2N1

Description

6-Fluoro-1H-benzo[d]imidazole-2-carbaldehyde features a fluorinated benzimidazole core with a formyl group at the 2-position, delivering enhanced electron-withdrawing character and improved solubility in polar solvents. This scaffold enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS modulators. The fluorine substituent enhances metabolic stability and membrane permeability, while the aldehyde functionality provides a direct handle for reductive amination or hydrazone formation.

Application

6-Fluoro-1H-benzo[d]imidazole-2-carbaldehyde serves as a versatile building block for heterocyclic synthesis, enabling efficient access to biologically relevant scaffolds. The aldehyde functionality facilitates nucleophilic additions and condensation reactions, while the fluorine substituent enhances metabolic stability and modulates electronic properties. This compound exhibits excellent bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 45.75
LogP 1.5145
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Benzimidazole compounds

Key Words

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6-Fluoro-1H-benzo[d]imidazole-2-carbaldehyde

CAS No. 885280-34-2

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