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CS-W001157 4
Total: USD 88.00

1-Boc-1,8-diaza-spiro[4.5]decane

  • CAS No. 885279-92-5

  • Cat. No. CS-0000550
  • Purity≥95%
  • MDL No.MFCD06739037

*For research and further manufacturing use only, not for direct human use.

1-Boc-1,8-diaza-spiro[4.5]decane|CS-0000550

Structure of 885279-92-5

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General Information

  • CAS No. 885279-92-5
  • Cat. No. CS-0000550
  • Purity ≥95%
  • MDL No. MFCD06739037
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₂₄N₂O₂
  • Molecular Weight 240.34
  • Synonym(s) Tert-butyl 1,8-diazaspiro[4.5]decane-1-carboxylate
  • SMILES O=C(OC(C)(C)C)N(CCC1)C21CCNCC2

Description

1-Boc-1,8-diaza-spiro[4.5]decane features a rigid spirocyclic scaffold with two nitrogen atoms positioned at strategic vertices, enabling efficient stereocontrol in asymmetric synthesis. The Boc group provides a stable, moisture-tolerant protecting group for amine derivatization under standard conditions. This compound integrates seamlessly into catalytic systems requiring bifunctional nitrogen donors and serves as a modular building block for complex heterocyclic architectures.

Application

1-Boc-1,8-diaza-spiro[4.5]decane serves as a robust, bench-stable chiral auxiliary and nitrogen-containing scaffold in synthetic organic chemistry. Its rigid spirocyclic structure enables precise stereocontrol in asymmetric synthesis, while the Boc group offers convenient protection and orthogonal deprotection under mild acidic conditions. This compound facilitates efficient construction of complex heterocycles and functionalized amines, with demonstrated utility in catalytic reactions and peptide-based molecule assembly.

Synthesis

  • Route1
    • 1,8-Diazaspiro[4.5]decane-1-carboxylic acid,8-(phenylmethyl)-, 1,1-dimethylethyl ester|CS-0000547
      928034-31-5
    • ~%
    • In-stock
      1-Boc-1,8-diaza-spiro[4.5]decane|CS-0000550
      885279-92-5

    References

    • WO2007/25069 A2, ; Page/Page column 27; 29-30 ; WO 2007/025069 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   2.1395
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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