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CS-W001157 4
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5-Bromo-2-methoxypyridin-3-amine

  • CAS No. 884495-39-0

  • Cat. No. CS-M0124
  • Purity≥98%
  • MDL No.MFCD07368887

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-methoxypyridin-3-amine|CS-M0124

Structure of 884495-39-0

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General Information

  • CAS No. 884495-39-0
  • Cat. No. CS-M0124
  • Purity ≥98%
  • MDL No. MFCD07368887
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BrN₂O
  • Molecular Weight 203.04
  • Synonym(s) 5-bromo-2-methoxy-pyridin-3-amine
  • SMILES NC1=C(OC)N=CC(Br)=C1

Description

5-Bromo-2-methoxypyridin-3-amine features a pyridine core functionalized with bromo and methoxy groups at the 5- and 2-positions, respectively, and an amino group at C3. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct coupling reactions and facilitating the synthesis of bioactive compounds through palladium-catalyzed cross-coupling processes.

Application

5-Bromo-2-methoxypyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined bromine handle and amine functionality. The methoxy group enhances solubility and modulates electronic properties, while the compound exhibits excellent bench stability and facilitates straightforward purification. It functions as a key intermediate for constructing bioactive heterocycles and API scaffolds in drug discovery workflows.

Synthesis

  • Route1

    References

    • WO2008/33854 A1, ; Page/Page column 74-75 ;
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1569 - 1574
  • Route3

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 4 p. 1569 - 1574

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H317-H318-H335
Precautionary Statements : P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.4349
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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