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CS-W001157 4
Total: USD 88.00

2-Chloro-5-fluoroisonicotinic acid

  • CAS No. 884494-74-0

  • Cat. No. CS-D0438
  • Purity≥97%
  • MDL No.MFCD04972381

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-fluoroisonicotinic acid|CS-D0438

Structure of 884494-74-0

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General Information

  • CAS No. 884494-74-0
  • Cat. No. CS-D0438
  • Purity ≥97%
  • MDL No. MFCD04972381
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClFNO₂
  • Molecular Weight 175.54
  • Synonym(s) 2-Chloro-5-fluoropyridine-4-carboxylic acid
  • SMILES O=C(C1=CC(Cl)=NC=C1F)O

Description

2-Chloro-5-fluoroisonicotinic acid is a fluorinated pyridine carboxylic acid featuring strategically positioned halogen substituents. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds, offering enhanced metabolic stability and improved binding affinity in target-directed synthesis. The molecule exhibits favorable solubility profiles under standard conditions and serves as a key intermediate in the development of bioactive compounds.

Application

2-Chloro-5-fluoroisonicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-chloro and para-fluoro substituents provide enhanced reactivity in nucleophilic aromatic substitution and Suzuki coupling reactions, while maintaining bench stability and compatibility with common protecting group strategies.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.5723
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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