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CS-W001157 4
Total: USD 88.00

4-Amino-1H-indole-6-carboxylic acid

  • CAS No. 884494-67-1

  • Cat. No. CS-0163690
  • Purity≥95%
  • MDL No.MFCD03094987

*For research and further manufacturing use only, not for direct human use.

4-Amino-1H-indole-6-carboxylic acid|CS-0163690

Structure of 884494-67-1

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General Information

  • CAS No. 884494-67-1
  • Cat. No. CS-0163690
  • Purity ≥95%
  • MDL No. MFCD03094987
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O₂
  • Molecular Weight 176.17
  • Synonym(s) 4-AMINOINDOLE-6-CARBOXYLIC ACID
  • SMILES O=C(C1=CC2=C(C(N)=C1)C=CN2)O

Description

4-Amino-1H-indole-6-carboxylic acid features a fused bicyclic indole core with strategically positioned amino and carboxylic acid groups. This combination enables direct incorporation into bioactive molecule scaffolds, offering enhanced solubility and hydrogen-bonding capacity for medicinal chemistry applications. The electron-rich indole system supports further functionalization under mild conditions.

Application

4-Amino-1H-indole-6-carboxylic acid serves as a versatile building block for the synthesis of indole-based pharmaceuticals and agrochemicals. Its dual functionality—amine and carboxylic acid—enables straightforward amide coupling, reductive amination, and derivatization under standard conditions. The molecule exhibits good bench stability and facilitates efficient purification via crystallization or ion-exchange chromatography, making it well-suited for iterative synthetic campaigns in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   79.11
  • LogP   1.4483
  • H_Acceptors   2
  • H_Donors   3
  • Rotatable_Bonds   1

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