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CS-W001157 4
Total: USD 88.00

3-Bromo-2-fluoro-4-iodopyridine

  • CAS No. 884494-52-4

  • Cat. No. CS-0041091
  • Purity≥97%
  • MDL No.MFCD03095311

*For research and further manufacturing use only, not for direct human use.

3-Bromo-2-fluoro-4-iodopyridine|CS-0041091

Structure of 884494-52-4

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General Information

  • CAS No. 884494-52-4
  • Cat. No. CS-0041091
  • Purity ≥97%
  • MDL No. MFCD03095311
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrFIN
  • Molecular Weight 301.88
  • Synonym(s) None
  • SMILES IC1=C(Br)C(F)=NC=C1

Description

3-Bromo-2-fluoro-4-iodopyridine features a trihalogenated pyridine core with distinct electronic and steric properties. The ortho-fluoro and bromo substituents enhance regioselectivity in cross-coupling reactions, while the para-iodo group enables efficient palladium-catalyzed functionalization. This molecule serves as a key building block for pharmaceutical intermediates and advanced heterocyclic scaffolds.

Application

3-Bromo-2-fluoro-4-iodopyridine serves as a versatile trihalogenated pyridine building block for transition-metal-catalyzed cross-coupling reactions. Its orthogonal halogen reactivity enables sequential functionalization at distinct positions, facilitating the construction of complex heterocyclic scaffolds. The molecule exhibits excellent bench stability and compatibility with palladium- and nickel-based catalytic systems, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.5878
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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