2-Chloro-5-fluoro-4-iodopyridine

Name: 2-Chloro-5-fluoro-4-iodopyridine
Brand: ChemScene
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CAS No. 884494-49-9
Cat. No. CS-W000348
Purity≥98%
MDL No.MFCD03095306

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-fluoro-4-iodopyridine|CS-W000348

Structure of 884494-49-9

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General Information

CAS No. 884494-49-9
Cat. No. CS-W000348
Purity ≥98%
MDL No. MFCD03095306
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂ClFIN
Molecular Weight 257.43
Synonym(s) Methyl 7-bromopicolinate
SMILES IC1=CC(Cl)=NC=C1F

Description

2-Chloro-5-fluoro-4-iodopyridine is a trihalogenated pyridine scaffold enabling precise diversification in cross-coupling workflows. The ortho-chloro and para-fluoro substituents facilitate selective palladium-catalyzed functionalization, while the iodine handle delivers high reactivity in Suzuki, Stille, and Negishi transformations. This electron-deficient heterocycle offers enhanced stability under standard reaction conditions.

Application

2-Chloro-5-fluoro-4-iodopyridine serves as a versatile trifunctional pyridine building block for transition-metal-catalyzed cross-coupling reactions. The orthogonal reactivity of its halogen substituents enables sequential functionalization, with the iodide undergoing palladium-catalyzed coupling under mild conditions while the chloro and fluoro groups remain stable. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex heterocyclic scaffolds in medicinal chemistry and agrochemical synthesis.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 12.89
LogP 2.4787
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-fluoro-4-iodopyridine

CAS No. 884494-49-9

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