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CS-W001157 4
Total: USD 88.00

5,6-Dimethoxy-1H-indole-2-carboxylic acid

  • CAS No. 88210-96-2

  • Cat. No. CS-0131945
  • Purity≥98%
  • MDL No.MFCD00015459

*For research and further manufacturing use only, not for direct human use.

5,6-Dimethoxy-1H-indole-2-carboxylic acid|CS-0131945

Structure of 88210-96-2

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General Information

  • CAS No. 88210-96-2
  • Cat. No. CS-0131945
  • Purity ≥98%
  • MDL No. MFCD00015459
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₁NO₄
  • Molecular Weight 221.21
  • Synonym(s) 5,6-dimethoyxindole-2-carboxylic acid
  • SMILES O=C(C(N1)=CC2=C1C=C(OC)C(OC)=C2)O

Description

5,6-Dimethoxy-1H-indole-2-carboxylic acid features two methoxy groups at the 5- and 6-positions of the indole ring, enhancing electron density and solubility. This derivative serves as a key building block in medicinal chemistry, particularly for developing bioactive compounds with improved metabolic stability and membrane permeability.

Synthesis

  • Route1
    • Methyl 5,6-dimethoxy-1h-indole-2-carboxylate|CS-0217638
      28059-24-7
    • ~99%
    • In-stock
      5,6-Dimethoxy-1H-indole-2-carboxylic acid|CS-0131945
      88210-96-2

    References

    • The Scripps Research Institute Patent: US2005/26987 A1, 2005 ; Location in patent: Page 20 ;
  • Route2

    References

    • Choi, Taeyoung; Ma, Eunsook Archives of Pharmacal Research, 2011 , vol. 34, # 3 p. 357 - 367
  • Route3
    • L-Tyrosine Levodopa Impurity|CS-0229709
      60-18-4
    • ~%
    • In-stock
      5,6-Dimethoxy-1H-indole-2-carboxylic acid|CS-0131945
      88210-96-2

    References

    • Journal of the Chemical Society, , p. 2061,2064 Biochemical Journal, , vol. 21, p. 95 Physiol. Rev., , vol. 30, p. 96 Journal of Biological Chemistry, , vol. 172, p. 83,90, 94

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   71.55
  • LogP   1.8833
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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