2-Chloro-5-fluoro-4-methylpyridine

Name: 2-Chloro-5-fluoro-4-methylpyridine
Brand: ChemScene
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CAS No. 881891-83-4
Cat. No. CS-W003672
Purity≥98%
MDL No.MFCD09864695

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Chloro-5-fluoro-4-methylpyridine|CS-W003672

Structure of 881891-83-4

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General Information

CAS No. 881891-83-4
Cat. No. CS-W003672
Purity ≥98%
MDL No. MFCD09864695
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClFN
Molecular Weight 145.56
Synonym(s) 2-Chloro-5-fluoro-4-methyl-pyridine
SMILES Clc1ncc(c(c1)C)F

Description

2-Chloro-5-fluoro-4-methylpyridine features a trifunctional pyridine core with orthogonal reactivity, enabling selective transformations in late-stage functionalization. The chloro and fluoro substituents enhance electrophilic susceptibility, while the methyl group provides steric stabilization. This compound serves as a key building block for bioactive heterocycles in medicinal chemistry and agrochemical synthesis.

Application

2-Chloro-5-fluoro-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its ortho-chloro and meta-fluoro substituents provide complementary reactivity for selective derivatization, while the methyl group enhances metabolic stability. The compound exhibits excellent bench stability and compatibility with diverse reaction conditions, facilitating rapid access to substituted pyridine scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 12.89
LogP 2.18252
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Chloro-5-fluoro-4-methylpyridine

CAS No. 881891-83-4

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