5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

Name: 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
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CAS No. 881677-11-8
Cat. No. CS-0160769
Purity≥98%
MDL No.MFCD11875978

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5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde|CS-0160769

Structure of 881677-11-8

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General Information

CAS No. 881677-11-8
Cat. No. CS-0160769
Purity ≥98%
MDL No. MFCD11875978
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₁₁FN₂O₃S
Molecular Weight 330.34
Synonym(s) None
SMILES O=CC1=CN(S(=O)(C2=CC=CN=C2)=O)C(C3=CC=CC=C3F)=C1

Description

This pyrrole-based aldehyde features a fluorinated aryl group and a pyridine sulfonamide moiety, delivering enhanced electronic modulation and solubility. The para-fluorophenyl substitution improves metabolic stability, while the sulfonylpyridine handle enables efficient conjugation in synthetic workflows. Bench-stable under standard conditions, this compound integrates readily into complex molecular architectures.

Application

5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via standard coupling and functional group transformation protocols. The pyrrole core exhibits stability under routine reaction conditions, while the aldehyde functionality facilitates efficient derivatization through reductive amination, cyanohydrin formation, or condensation reactions. The ortho-fluorophenyl and pyridinylsulfonyl groups provide enhanced metabolic stability and tunable solubility, supporting downstream optimization in API development workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 69.03
LogP 2.7387
H_Acceptors 5
H_Donors 0
Rotatable_Bonds 4

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrrole compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde

CAS No. 881677-11-8

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