5-Bromo-2-chloro-4-methoxypyridine

Name: 5-Bromo-2-chloro-4-methoxypyridine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 880870-13-3
Cat. No. CS-W004187
Purity≥97%
MDL No.MFCD09909843

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Bromo-2-chloro-4-methoxypyridine|CS-W004187

Structure of 880870-13-3

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General Information

CAS No. 880870-13-3
Cat. No. CS-W004187
Purity ≥97%
MDL No. MFCD09909843
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅BrClNO
Molecular Weight 222.47
Synonym(s) None
SMILES COc1cc(Cl)ncc1Br

Description

5-Bromo-2-chloro-4-methoxypyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling and functionalization. The bromo group enables palladium-catalyzed coupling, while the chloro and methoxy substituents offer orthogonal reactivity and enhanced solubility. This scaffold integrates efficiently into complex molecular architectures under standard conditions.

Application

5-Bromo-2-chloro-4-methoxypyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki, Stille, or Negishi coupling under standard conditions, while the chloro and methoxy functionalities offer predictable regioselectivity and enhanced stability for bench-scale operations. This compound functions reliably in the construction of complex pyridine-based scaffolds relevant to medicinal chemistry and agrochemical development.

Synthesis

Route1
- In-stock
  
  17228-69-2
- ~43%
- In-stock
  
  880870-13-3
References
- Satoh, Motohide; Aramaki, Hisateru; Nakamura, Hiroshi; Inoue, Masafumi; Kawakami, Hiroshi; Shinkai, Hisashi; Matsuzaki, Yuji; Yamataka, Kazunobu Patent: US2006/84665 A1, 2006 ; Location in patent: Page/Page column 49 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 22.12
LogP 2.5061
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Bromo-2-chloro-4-methoxypyridine

CAS No. 880870-13-3

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