Lot numbers can be found on the outside label of a product:
(R)-tert-Butyl1-(benzylamino)-3-methoxy-1-oxopropan-2-ylcarbamate
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CAS No. 880468-89-3
- Cat. No. CS-0006747
- Purity≥98%
- MDL No.MFCD16620517
*For research and further manufacturing use only, not for direct human use.
Structure of 880468-89-3
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General Information
- CAS No. 880468-89-3
- Cat. No. CS-0006747
- Purity ≥98%
- MDL No. MFCD16620517
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₆H₂₄N₂O₄
- Molecular Weight 308.37
- Synonym(s) O-methyl-N-alpha-[phenylmethoxy]carbonyl]-N-(phenylmethyl)-D-Serinamide
- SMILES O=C(OC(C)(C)C)N[C@H](COC)C(NCC1=CC=CC=C1)=O
Description
This orthogonally-protected diaminopropionic acid derivative is based on the hindered Dde variant ivDde. The side-chain ivDde group is considerably more stable to piperidine than Dde and is less prone to migrate from protected to unprotected side-chains [1]. However, migration from side-chain to the unprotected -amino group of Dpr is unavoidable [2]. This side-reaction can, however, be minimized by the appropriate choice of coupling method for the subsequent residue, see [3].When removing ivDde in the presence of allyl-based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group [4]. Associated Protocols and Technical ArticlesCleavage and Deprotection Protocols for Fmoc SPPSLiterature references[1] S. R. Chhabra, et al. (1998) Tetrahedron Lett., 39, 1603. [2] R. Wilhelm, et al., Poster 34 presented at the 16th American Peptide Symposium, Minneapolis, 1999. [3] J. Beythien & P. Schneeberger, in Peptides 2000, Proc. 26th European Peptide Symposium, EDK, Paris, 2001, pp. 361. [4] B. Rohwedder, et al. (1998) Tetrahedron Lett., 39, 1175.
Synthesis
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Route1
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In-stock
3850-40-6 - ~%
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In-stock
880468-89-3
References
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MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; SRINIVAS, Aluru; SATYANARAYANA, Revu Patent: WO2011/99033 A1, 2011 ;
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Route2
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In-stock
3850-40-6
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100-46-9 - ~%
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In-stock
880468-89-3
References
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Archimica GmbH Patent: EP2399901 A1, 2011 ;
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Route3
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In-stock
1253790-58-7 -
77-78-1
- ~77%
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In-stock
880468-89-3
References
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WISDOM, Richard; JUNG, Joerg; MEUDT, Andreas Patent: US2011/319649 A1, 2011 ; Location in patent: Page/Page column 5 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H332-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 76.66
- LogP 1.8425
- H_Acceptors 4
- H_Donors 2
- Rotatable_Bonds 6
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Key Words
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